Title: Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice. Neurobiol Dis. 2025 May 15
The paper reports on how the mouse data reveals the presence but also the differential impact of the p.D801N and p.E815K variants on disease in AHC. Relevant alterations such as spontaneous and stress-induced paroxysmal episodes, motor function, behavioral and neurophysiological activity, and neuroinflammation are identified. We are so thankful to everyone who worked on this important and complex study. It will be of great use to the AHC community for years to come. Be sure to check out the full text of the paper on the web.
Link: https://www.sciencedirect.com/science/article/pii/S0969996125001706?via%3Dihub
