Mood disorders and neuropsychiatric problems are commonly associated with AHC.
Common Mood and Behavioral Disorders
- Depressive disorder is reported among AHC patients, often accompanied by executive function and language impairments.
- Anxiety disorder, along with hyperarousal symptoms, is seen in many children with the condition.
- Disruptive mood dysregulation behavior, general disruptive behavior, and aggression are prevalent.
- ADHD (attention-deficit/hyperactivity disorder) and cognitive impairment are common comorbidities.
- Social impairments mimicking autism spectrum disorder and obsessive-compulsive behaviors have also been linked.
- Sleep disorders, especially insomnia and sleep-disordered breathing, can contribute to behavioral and mood challenges.
Clinical Significance
People with AHC are at elevated risk for mood and behavioral disorders, requiring routine neuropsychological and psychiatric evaluation to optimize long-term care. Early detection and multidisciplinary management are critical due to the complex nature of both the neurological and psychiatric symptoms.
Source: Wallace K, Uchitel J, Prange L. Characterization of Severe and Extreme Behavioral Problems in Patients with Alternating Hemiplegia of Childhood. Pediatric Neurology, 2020; 111, 5-12. https://doi.org/10.1016/j.pediatrneurol.2020.06.012